Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.35 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.35 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 6/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24067683 | 1.00 | PIP4K2A (0.36) | PIP4K2ANAE1CA2GRK5CSNK1A1 | |
| SCHEMBL25948725 | 0.80 | ALDH1A1 (0.34) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL18572220 | 0.80 | ALDH1A1 (0.34) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL21312932 | 0.78 | NNMT (0.33) | NNMT | |
| SCHEMBL29540340 | 0.77 | NNMT (0.40) | NNMT | |
| SCHEMBL2740566 | 0.77 | NAE1 (0.44) | PIP4K2ANAE1CA2GRK5CSNK1A1 | |
| SCHEMBL10186281 | 0.77 | NAE1 (0.44) | PIP4K2ANAE1CA2GRK5CSNK1A1 | |
| SCHEMBL18572001 | 0.76 | NNMT (0.35) | NNMT | |
| SCHEMBL25049187 | 0.76 | PIP4K2A (0.39) | PIP4K2ANNMTSLC22A12ADCY5 | |
| SCHEMBL20049521 | 0.76 | PIP4K2A (0.39) | PIP4K2AACACBNNMTSLC22A12ADCY5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |