Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ATG7 | O95352 | 3/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.30 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.30 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.30 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892451 | 0.87 | — | — | |
| SCHEMBL23892392 | 0.79 | PRMT5 (0.51) | PRMT5WDR77 | |
| SCHEMBL23892253 | 0.76 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL23892203 | 0.70 | ALDH1A1 (0.36) | — | |
| SCHEMBL25949042 | 0.69 | GPR119 (0.33) | — | |
| SCHEMBL23584456 | 0.69 | ADK (0.47) | PRMT5BCHEWDR77 | |
| SCHEMBL20938199 | 0.67 | PRMT5 (0.44) | PRMT5BCHEWDR77 | |
| SCHEMBL23892274 | 0.67 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23892446 | 0.67 | ALDH1A1 (0.34) | — | |
| SCHEMBL18464362 | 0.65 | ADK (0.57) | ATG7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |