Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.34 |
| ▸ | USP2 | O75604 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585625 | 0.78 | RIPK3 (0.35) | MAP3K11RIPK1RIPK3PIM1PIM2 | |
| SCHEMBL2585288 | 0.76 | CD38 (0.33) | RIPK1RIPK3PIM1PIM2 | |
| SCHEMBL14717763 | 0.75 | RIPK2 (0.50) | PIK3CAMTORRIPK1RIPK3 | |
| SCHEMBL2595034 | 0.72 | RIPK3 (0.34) | MAP3K11RIPK1RIPK3PIM1PIM2 | |
| SCHEMBL2595324 | 0.68 | RIPK2 (0.38) | RIPK1RIPK3 | |
| SCHEMBL2594418 | 0.67 | PIK3CA (0.41) | PIK3CAMTOR | |
| SCHEMBL2588243 | 0.66 | RIPK3 (0.39) | MAP3K11RIPK1RIPK3PIM1PIM2 | |
| SCHEMBL2588246 | 0.66 | RIPK3 (0.36) | MAP3K11RIPK1RIPK3PIM1PIM2 | |
| SCHEMBL2595020 | 0.65 | PDE4B (0.50) | RIPK1RIPK3 | |
| SCHEMBL2595613 | 0.64 | RIPK2 (0.35) | RIPK1RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140442-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-10 | — | — | WO | disclosed |