Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28131951 | 0.73 | OPRM1 (0.47) | PARP1KDM4E | |
| SCHEMBL19910582 | 0.72 | GABRA1 (0.36) | — | |
| SCHEMBL14917590 | 0.72 | EZH2 (0.48) | PARP1PARP2IRAK4KDM4EADRA1D | |
| SCHEMBL2592776 | 0.72 | PARP1 (0.43) | PARP1PARP2IRAK4KDM4EPARP3 | |
| SCHEMBL30385795 | 0.70 | KDM4E (0.48) | PARP1IRAK4KDM4E | |
| SCHEMBL28131230 | 0.70 | NR4A2 (0.44) | KDM4E | |
| SCHEMBL28193823 | 0.67 | PARP1 (0.43) | PARP1PARP2KDM4ETLR8 | |
| SCHEMBL23482802 | 0.67 | ALDH1A1 (0.30) | — | |
| SCHEMBL3334681 | 0.66 | IRAK4 (0.46) | PARP1PARP2IRAK4KDM4EADRA1D | |
| SCHEMBL2594981 | 0.66 | MYC (0.37) | KDM4EEZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566327-A1 | INDOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | claimed |
| WO-2011140324-A1 | INDOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | claimed |