SCHEMBL2595321

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2594697	0.85	PDE1A (0.40)	KDM4EKMT2AKMOPDE1APDE1B
	SCHEMBL23809208	0.84	KDM4E (0.55)	KDM4EKMT2APDE1APDE1BPDE1C
	SCHEMBL31474839	0.82	KDM4E (0.53)	KDM4EKMT2APDE1APDE1BPDE1C
	SCHEMBL2588942	0.82	KDM4E (0.53)	KDM4EKMT2APDE1APDE1BPDE1C
	SCHEMBL12180845	0.82	KDM4E (0.53)	KDM4EKMT2APDE1APDE1BPDE1C
	SCHEMBL20365096	0.78	ACLY (0.41)	KDM4EKMT2AKMOPDE1APDE1B
	SCHEMBL12499174	0.78	CREBBP (0.45)	KDM4EKMT2AKMOAKR1C4AKR1C3
	SCHEMBL2594393	0.76	EZH2 (0.51)	KDM4EKMT2AEZH2HPGDHCAR3
	SCHEMBL29846416	0.76	EZH2 (0.51)	KDM4EKMT2AEZH2HPGDHCAR3
	SCHEMBL1694749	0.75	KDM4E (0.71)	KDM4EKMT2AKMOPDE1CEZH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.