Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8194928 | 0.85 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1TDP1GRIN2D | |
| SCHEMBL17084499 | 0.83 | GPR35 (0.41) | MEN1KMT2AALDH1A1TDP1TSHR | |
| SCHEMBL18937751 | 0.81 | MAPT (0.36) | MEN1KMT2AALDH1A1TDP1HPGD | |
| SCHEMBL31347217 | 0.81 | GRIN2D (0.40) | MEN1KMT2AALDH1A1TDP1GRIN2D | |
| SCHEMBL1366268 | 0.81 | GRIN2D (0.40) | MEN1KMT2AALDH1A1TDP1GRIN2D | |
| SCHEMBL9942607 | 0.81 | TDP1 (0.34) | MEN1KMT2AALDH1A1TDP1TSHR | |
| SCHEMBL8884167 | 0.77 | MEN1 (0.42) | MEN1KMT2AALDH1A1TDP1GRIN2D | |
| SCHEMBL10415524 | 0.77 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL17517329 | 0.74 | MEN1 (0.41) | MEN1KMT2AALDH1A1TDP1GRIN2D | |
| SCHEMBL31539684 | 0.73 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1TDP1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4218766-A1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | Incyte Holdings Corporation (US) | 2023-08-02 | — | — | EP | disclosed |