Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25955665 | 0.81 | MEN1 (0.42) | TDP1ALDH1A1MEN1KMT2AGPR35 | |
| SCHEMBL17084499 | 0.80 | GPR35 (0.41) | TDP1ALDH1A1MEN1KMT2AGPR35 | |
| SCHEMBL18937751 | 0.79 | MAPT (0.36) | TDP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL31347217 | 0.79 | GRIN2D (0.40) | TDP1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL1366268 | 0.79 | GRIN2D (0.40) | TDP1ALDH1A1MEN1KMT2AGPR35 | |
| SCHEMBL8194928 | 0.74 | ALDH1A1 (0.41) | TDP1ALDH1A1MEN1KMT2AGPR35 | |
| SCHEMBL27562898 | 0.70 | HSP90AA1 (0.43) | MEN1KMT2AMAPTHTT | |
| SCHEMBL2033648 | 0.68 | GPR35 (0.39) | TDP1ALDH1A1GPR35TSHRLMNA | |
| SCHEMBL801243 | 0.67 | ALDH1A1 (0.50) | TDP1ALDH1A1MEN1KMT2AGPR35 | |
| SCHEMBL31539684 | 0.67 | ALDH1A1 (0.41) | TDP1ALDH1A1MEN1KMT2AGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363705-B9 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2012-11-07 | — | — | EP | disclosed |
| EP-1363705-B1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2012-06-13 | — | — | EP | disclosed |