Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2835404 | 0.84 | EGFR (0.40) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL25331492 | 0.81 | NPSR1 (0.36) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL21581650 | 0.77 | DRD1 (0.44) | KMT2AMEN1HAO1MAP4K4PPARG | |
| SCHEMBL2831891 | 0.76 | LIPE (0.35) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL23952709 | 0.74 | KDM4E (0.46) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL26186440 | 0.74 | AR (0.39) | SMN1; SMN2MAPTLMNANPSR1KMT2A | |
| SCHEMBL257919 | 0.73 | TEAD4 (0.48) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL257852 | 0.71 | SOS1 (0.50) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL12907980 | 0.70 | GRM2 (0.43) | PPARGFFAR4 | |
| SCHEMBL19510766 | 0.70 | ALDH1A1 (0.55) | NPC1RAB9ASMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4223753-A1 | AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2023-08-09 | — | — | EP | disclosed |