Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 5/20 | 0.71 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.59 |
| ▸ | CDC25A | P30304 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743075 | 0.86 | CDC25A (0.70) | ICMTBRCA1CDC25ANR4A2PLK1 | |
| SCHEMBL10965765 | 0.84 | ICMT (0.71) | ICMTCDC25APLA2G2A | |
| SCHEMBL3667313 | 0.84 | ICMT (0.97) | ICMTCDC25A | |
| SCHEMBL27837583 | 0.84 | ICMT (0.62) | ICMTCDC25APLA2G2APLK1KDM4E | |
| SCHEMBL11893393 | 0.83 | ICMT (1.00) | ICMTCDC25A | |
| SCHEMBL5253839 | 0.83 | ICMT (0.69) | ICMTCDC25APLA2G2A | |
| SCHEMBL8289938 | 0.82 | PLA2G2A (0.74) | ICMTPLA2G2AKMT2ALMNAPOLB | |
| SCHEMBL13228230 | 0.82 | NR4A2 (0.61) | ICMTBRCA1CDC25ANR4A2KMT2A | |
| SCHEMBL10654844 | 0.81 | CYP19A1 (0.56) | ICMTBRCA1CDC25ANR4A2PADI4 | |
| SCHEMBL30958421 | 0.81 | ICMT (0.62) | ICMTKMT2AMEN1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |