Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.68 |
| ▸ | MEN1 | O00255 | 10/20 | 0.68 |
| ▸ | MAPT | P10636 | 8/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.68 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.63 |
| ▸ | GAA | P10253 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | VCP | P55072 | 2/20 | 0.61 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.61 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.60 |
| ▸ | RELA | Q04206 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18769586 | 0.93 | MEN1 (0.79) | RAB9AKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL12298108 | 0.89 | MEN1 (0.78) | RAB9AKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL25959168 | 0.87 | RAB9A (0.64) | RAB9AKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL26307375 | 0.86 | CFTR (0.70) | RAB9AKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL25959109 | 0.86 | CYP1A1 (0.70) | RAB9AKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL1822611 | 0.86 | SMN1; SMN2 (0.84) | RAB9AKMT2AMEN1MAPTHTT | |
| SCHEMBL22560266 | 0.86 | RAB9A (0.73) | RAB9AKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL1819906 | 0.85 | RAB9A (0.78) | RAB9AKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL10072694 | 0.85 | ALOX5 (0.74) | RAB9AKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL23553571 | 0.84 | MAPT (0.74) | RAB9AKMT2AMEN1MAPTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286933-A1 | 2,5-ARYL-THIAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SOUTHERN RES INST (US) | 2023-09-14 | — | — | US | disclosed |
| US-11718593-B2 | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases | SOUTHERN RESEARCH INSTITUTE (US) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718593-B2 | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases | SMN1; SMN2, TDP2, TDP1 | RAB9A 2604/4885KMT2A 1259/4885MEN1 4743/4885 |
| US-20230286933-A1 | 2,5-ARYL-THIAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SMN1; SMN2, TDP2, TDP1 | RAB9A 2604/4885KMT2A 1259/4885MEN1 4743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.