Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11687169 | 0.98 | GLA (0.45) | KDM4EKEAP1SMN1; SMN2ALDH1A1RAB9A | |
| Bromide SCHEMBL28242666 | 0.98 | KDM4E (0.45) | KDM4EKEAP1SMN1; SMN2ALDH1A1RAB9A | |
| Acetic Acid SCHEMBL28231316 | 0.87 | GLA (0.50) | KDM4ESMN1; SMN2ALDH1A1RAB9AGLA | |
| SCHEMBL170765 | 0.86 | KEAP1 (0.54) | KDM4EKEAP1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL5254606 | 0.85 | KEAP1 (0.52) | KDM4EKEAP1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL11782938 | 0.83 | SMN1; SMN2 (0.50) | KDM4EKEAP1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL28720836 | 0.83 | SMN1; SMN2 (0.50) | KDM4EKEAP1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL9433442 | 0.83 | SMN1; SMN2 (0.50) | KDM4EKEAP1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL12719804 | 0.82 | — | — | |
| SCHEMBL646005 | 0.80 | KDM4E (0.50) | KDM4EKEAP1SMN1; SMN2ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11414429-B2 | Compound or pharmaceutically acceptable salt thereof | RIKEN (JP) | 2022-08-16 | — | — | US | disclosed |
| CN-110023315-B | Novel compound or pharmacologically acceptable salt thereof | 国立研究开发法人理化学研究所 | 2021-11-12 | — | — | CN | disclosed |
| EP-3480198-B1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | RIKEN (JP) | 2021-05-05 | — | — | EP | disclosed |
| US-20200172554-A1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | RIKEN (JP) | 2020-06-04 | — | — | US | disclosed |
| EP-3480198-A1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | RIKEN (JP) | 2019-05-08 | — | — | EP | disclosed |
| US-9932355-B2 | 2,5,6,7-tetrasubstituted thiazolo[4,5-b]pyridine derivatives and use thereof | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2018-04-03 | — | — | US | disclosed |
| US-20150307516-A1 | 2,5,6,7-tetrasubstituted Thiazolo[4,5-b]pyridine Derivatives and Use Thereof | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2015-10-29 | — | — | US | disclosed |
| EP-2386546-B1 | NOVEL PYRAZOLE-3-CARBOXAMIDE DERIVATE HAVING 5-HT2B RECEPTOR ANTAGONIST ACTIVITY | RAQUALIA PHARMA INC (JP) | 2015-08-19 | — | — | EP | disclosed |
| WO-2015072988-A1 | MESITYLENE SULFONATE COMPOSITIONS AND METHODS THEREOF | THE CLOROX COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |
| US-8455497-B2 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-04 | — | — | US | disclosed |
| WO-2007127135-A2 | ANTIBIOTIC COMPOUNDS | MERCK & CO., INC. (US) | 2007-11-08 | — | — | WO | disclosed |
| US-20070244186-A1 | 4, 7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation and Their Therapeutic Uses | IPSEN PHARMA S.A.S. (FR) | 2007-10-18 | — | — | US | disclosed |
| US-7238695-B2 | Imidazolyl derivatives | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, SAS (FR) | 2007-07-03 | — | — | US | disclosed |
| US-7220765-B2 | Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (SCRAS) (FR) | 2007-05-22 | — | — | US | disclosed |
| US-7199145-B2 | Derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D' 'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) | 2007-04-03 | — | — | US | disclosed |
| US-20070032653-A1 | N-{1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methylhexyl}-N-cyclohexylamine; agonists or antagonists of somatostatin receptors; acromegaly, restenosis, Crohn's disease, systemic sclerosis, external and internal pancreatic pseudocysts and ascites, nesidoblastosis, hyperinsulinism, gastrinoma, etc. | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. (FR) | 2007-02-08 | — | — | US | disclosed |
| US-20070021420-A1 | New derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments | SCRAS | 2007-01-25 | — | — | US | disclosed |
| US-4666461-A | Fuel treatment compositions | THE LUBRIZOL CORPORATION (US) | 1987-05-19 | — | — | US | disclosed |
| EP-0085510-B1 | COMPOSITIONS FOR USE IN ALCOHOL AND ALCOHOL CONTAINING FUELS | The Lubrizol Corporation (US) | 1986-04-16 | — | — | EP | disclosed |
| EP-0085510-A2 | Compositions for use in alcohol and alcohol containing fuels | The Lubrizol Corporation (US) | 1983-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021420-A1 | New derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments | ADCYAP1R1, HPRT1, ALPI | KDM4E 4419/4885KEAP1 1368/4885SMN1; SMN2 4788/4885 |
| US-11414429-B2 | Compound or pharmaceutically acceptable salt thereof | DPP8, DPP7, AZI2 | KDM4E 243/4885KEAP1 2841/4885SMN1; SMN2 928/4885 |
| US-20200172554-A1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | DPP8, DPP7, AZI2 | KDM4E 277/4885KEAP1 2880/4885SMN1; SMN2 1033/4885 |
| US-20070244186-A1 | 4, 7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation and Their Therapeutic Uses | CDC25C, CDC25A, CDC25B | KDM4E 723/4885KEAP1 1381/4885SMN1; SMN2 4692/4885 |
| US-20070032653-A1 | N-{1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methylhexyl}-N-cyclohexylamine; agonists or antagonists of somatostatin receptors; acromegaly, restenosis, Crohn's disease, systemic sclerosis, external and internal pancreatic pseudocysts and ascites, nesidoblastosis, hyperinsulinism, gastrinoma, etc. | GHSR, IGF1R, GIPR | KDM4E 4639/4885KEAP1 4198/4885SMN1; SMN2 1272/4885 |
| US-20150307516-A1 | 2,5,6,7-tetrasubstituted Thiazolo[4,5-b]pyridine Derivatives and Use Thereof | HMGB1, TLR4, HMGB2 | KDM4E 1430/4885KEAP1 476/4885SMN1; SMN2 1843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.