Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.46 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18778601 | 0.86 | CES2 (0.34) | ORAI1ORAI2ORAI3ENPP2NFE2L2 | |
| SCHEMBL29429847 | 0.85 | ENPP2 (0.50) | ORAI1ORAI2ORAI3ENPP2NFE2L2 | |
| SCHEMBL519872 | 0.85 | ENPP2 (0.50) | ORAI1ORAI2ORAI3ENPP2NFE2L2 | |
| SCHEMBL22972697 | 0.79 | NFE2L2 (0.44) | ORAI1ORAI2ORAI3ENPP2NFE2L2 | |
| SCHEMBL25720444 | 0.78 | SMN1; SMN2 (0.37) | KMT2AHPGDTP53KDM4ELMNA | |
| SCHEMBL203282 | 0.73 | ENPP2 (0.60) | ORAI1ORAI2ORAI3ENPP2L3MBTL1 | |
| SCHEMBL30868908 | 0.73 | ENPP2 (0.37) | ORAI1ORAI2ORAI3ENPP2NFE2L2 | |
| SCHEMBL4098184 | 0.70 | KMT2A (0.46) | ORAI1ORAI2ORAI3ENPP2NFE2L2 | |
| SCHEMBL30050189 | 0.70 | KMT2A (0.46) | ORAI1ORAI2ORAI3ENPP2NFE2L2 | |
| SCHEMBL19147471 | 0.70 | ENPP2 (0.75) | ORAI1ORAI2ORAI3ENPP2NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023137406-A1 | HETEROARYL COMPOUNDS AS HPK1 INHIBITORS AND METHODS OF USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2023-07-20 | — | — | WO | disclosed |