Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25960670 | 0.86 | IRAK4 (0.36) | IRAK4 | |
| SCHEMBL25960499 | 0.84 | JAK3 (0.33) | KMT2AIRAK4SYKJAK2JAK1 | |
| SCHEMBL25960910 | 0.82 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL25958904 | 0.82 | ALDH1A1 (0.37) | KMT2A | |
| SCHEMBL25960505 | 0.81 | JAK3 (0.32) | IRAK4JAK2JAK1TYK2JAK3 | |
| SCHEMBL25960805 | 0.80 | IRAK4 (0.34) | IRAK4 | |
| SCHEMBL25959229 | 0.80 | PCSK9 (0.39) | IRAK4 | |
| SCHEMBL25958326 | 0.79 | NNMT (0.42) | IRAK4JAK2JAK1TYK2 | |
| SCHEMBL25959270 | 0.78 | SCN9A (0.40) | KMT2AIRAK4 | |
| SCHEMBL25961330 | 0.71 | SYK (0.35) | IRAK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3870582-B1 | 5-AZAINDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2023-07-19 | — | — | EP | disclosed |