Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.50 |
| ▸ | TET3 | O43151 | 2/20 | 0.50 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL21603022 | 0.88 | SMN1; SMN2 (0.71) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28167490 | 0.87 | SMN1; SMN2 (0.88) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL31673489 | 0.87 | — | — | |
| Malic Acid SCHEMBL31673494 | 0.87 | — | — | |
| Malic Acid SCHEMBL29410671 | 0.87 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL14125844 | 0.87 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL856 | 0.87 | — | — | |
| Malic Acid SCHEMBL89131 | 0.87 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL256122 | 0.87 | — | — | |
| Malic Acid SCHEMBL98496 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194133-A | Analytical apparatus for medical diagnosis | THE GENERAL ELECTRIC COMPANY, P.L.C. (GB) | 1993-03-16 | — | — | US | claimed |
| EP-0455508-A1 | Sensor devices | THE GENERAL ELECTRIC COMPANY, p.l.c. (GB) | 1991-11-06 | — | — | EP | claimed |
| US-9988606-B2 | Generation of airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-05 | — | — | US | disclosed |
| US-20150247124-A1 | Generation of Airway and Lung Progenitors and Epithelial Cells and Three-Dimensional Anterior Foregut Spheres | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-09-03 | — | — | US | disclosed |
| US-20140038847-A1 | SCREENING AND CULTURING DEVICE AND METHODS FOR THE USE THEREOF | MICROSTEM, INC. (US) | 2014-02-06 | — | — | US | disclosed |
| WO-2014018691-A1 | GENERATION OF AIRWAY AND LUNG PROGENITORS AND EPITHELIAL CELLS AND THREE-DIMENSIONAL ANTERIOR FOREGUT SPHERES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-01-30 | — | — | WO | disclosed |
| US-20130130376-A1 | SCREENING METHODS, COMPOSITIONS IDENTIFIED THEREBY, TOOLS USEFUL FOR THE IDENTIFICATION THEREOF, AND CELL POPULATIONS PRODUCED THEREBY | SEROBYAN NAIRA (US) | 2013-05-23 | — | — | US | disclosed |
| EP-2566975-A2 | SCREENING METHODS, COMPOSITIONS IDENTIFIED THEREBY, TOOLS USEFUL FOR THE IDENTIFICATION THEREOF, AND CELL POPULATIONS PRODUCED THEREBY | Microstem, Inc. (US) | 2013-03-13 | — | — | EP | disclosed |
| EP-2199265-B1 | GLASS FIBER SIZING AGENT CONTAINING AMPHOTERIC POLYMER COMPOUND | NITTO BOSEKI CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |
| WO-2012065003-A2 | SCREENING AND CULTURING DEVICE AND METHODS FOR THE USE THEREOF | MICROSTEM, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| WO-2011139993-A2 | SCREENING METHODS, COMPOSITIONS IDENTIFIED THEREBY, TOOLS USEFUL FOR THE IDENTIFICATION THEREOF, AND CELL POPULATIONS PRODUCED THEREBY | MICROSTEM, INC. (US) | 2011-11-10 | — | — | WO | disclosed |
| US-20100215940-A1 | Glass Fiber Sizing Agent Containing Amphoteric Polymer Compound | NITTO BOSEKI CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| EP-2199265-A1 | GLASS FIBER SIZING AGENT CONTAINING AMPHOTERIC POLYMER COMPOUND | Nitto Boseki CO., LTD. (JP) | 2010-06-23 | — | — | EP | disclosed |