Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.77 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.77 |
| ▸ | LMNA | P02545 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | GAA | P10253 | 3/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | G6PD | P11413 | 2/20 | 0.77 |
| ▸ | PKM | P14618 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | MPI | P34949 | 1/20 | 0.77 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.72 |
| ▸ | STS | P08842 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13123060 | 1.00 | ESR1 (0.77) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL31544736 | 1.00 | ESR1 (0.77) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL1048371 | 1.00 | ESR1 (0.77) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL6883109 | 0.89 | ESR1 (0.73) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL6883111 | 0.89 | ESR1 (0.73) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL4665285 | 0.89 | ESR1 (0.66) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL224399 | 0.87 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL6009933 | 0.87 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL13123059 | 0.87 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL224398 | 0.87 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991621-B1 | TWO-LAYER OCULAR IMPLANT | RETINA FOUND OF THE SOUTHWEST (US) | 2020-12-09 | — | — | EP | claimed |
| JP-4228116-B2 | — | — | 2009-02-25 | — | — | JP | claimed |
| US-20080171730-A1 | Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes and vascular and renal disorders | UNIVERSITY OF PITTSBURGH (US) | 2008-07-17 | — | — | US | claimed |
| EP-1829529-A1 | Controlled release compositions of estradiol metabolites | PR Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| EP-1418876-A4 | ADMINISTRATION OF ESTRADIOL METABOLITES FOR THE TREATMENT OR PREVENTION OF OBESITY, METABOLIC SYNDROME, DIABETES, AND VASCULAR AND RENAL DISORDERS | UNIV PITTSBURGH (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1507514-B1 | CONTROLLED RELEASE COMPOSITIONS OF ESTRADIOL METABOLITES | PR PHARMACEUTICALS INC (US) | 2007-02-14 | — | — | EP | claimed |
| US-20060083778-A1 | Controlled release compositions of estradiol metabolites | PR PHARMACEUTICALS INC. | 2006-04-20 | — | — | US | claimed |
| EP-1507514-A4 | CONTROLLED RELEASE COMPOSITIONS OF ESTRADIOL METABOLITES | PR PHARMACEUTICALS INC (US) | 2005-08-10 | — | — | EP | claimed |
| EP-1549292-A2 | PHARMACEUTICAL PREPARATIONS, USE OF SAID PREPARATIONS AND METHOD FOR INCREASING THE BIOAVAILABILITY OF MEDICAMENTS FOR PERORAL ADMINISTRATION | Schering Aktiengesellschaft (DE) | 2005-07-06 | — | — | EP | claimed |
| EP-1507514-A2 | CONTROLLED RELEASE COMPOSITIONS OF ESTRADIOL METABOLITES | PR Pharmaceuticals, Inc. (US) | 2005-02-23 | — | — | EP | claimed |
| WO-2003092585-A2 | CONTROLLED RELEASE COMPOSITIONS OF ESTRADIOL METABOLITES | PR PHARMACEUTICALS, INC. (US) | 2003-11-13 | — | — | WO | claimed |
| US-20030050294-A1 | Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes, and vascular and renal disorders | PITTSBURGH, UNIVERSITY OF | 2003-03-13 | — | — | US | claimed |
| WO-2003015704-A2 | ADMINISTRATION OF ESTRADIOL METABOLITES FOR THE TREATMENT OR PREVENTION OF OBESITY, METABOLIC SYNDROME, DIABETES, AND VASCULAR AND RENAL DISORDERS | UNIVERSITY OF PITTSBURGH (US) | 2003-02-27 | — | — | WO | claimed |
| EP-0923376-A4 | TREATMENT OF ASTHMA AND AIRWAY DISEASES | AMRAD OPERATIONS PTY LTD (AU) | 2001-09-26 | — | — | EP | claimed |
| JP-2000507923-A | — | — | 2000-06-27 | — | — | JP | claimed |
| EP-0923376-A1 | TREATMENT OF ASTHMA AND AIRWAY DISEASES | Amrad Operations Pty.,Ltd. (AU) | 1999-06-23 | — | — | EP | claimed |
| WO-1999001142-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANGIOSTATIC STEROID COMBINED WITH A HYALURONAN | HYAL PHARMACEUTICAL CORPORATION (CA) | 1999-01-14 | — | — | WO | claimed |
| EP-0866969-A1 | METHOD OF CANCER DETECTION | IMMUNA CARE CORPORATION (US) | 1998-09-30 | — | — | EP | claimed |
| WO-1997042958-A1 | TREATMENT OF ASTHMA AND AIRWAY DISEASES | AMRAD OPERATIONS PTY. LTD. (AU) | 1997-11-20 | — | — | WO | claimed |
| WO-1997011374-A1 | METHOD OF CANCER DETECTION | IMMUNA CARE CORPORATION (US) | 1997-03-27 | — | — | WO | claimed |