SCHEMBL2596566

SCHEMBL2596566

O=C(O)CCC(=O)OC(=O)CI

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 5/20 0.45
LMNA P02545 5/20 0.45
ALKBH5 Q6P6C2 1/20 0.45
SUCNR1 Q9BXA5 1/20 0.45
KDM5C P41229 4/20 0.43
PHF8 Q9UPP1 4/20 0.43
KDM2A Q9Y2K7 4/20 0.43
KDM6B O15054 3/20 0.43
ALDH1A1 P00352 2/20 0.40
SLC15A2 Q16348 1/20 0.36
MAPK1 P28482 1/20 0.36
SLC13A3 Q8WWT9 1/20 0.36
OR51E2 Q9H255 1/20 0.36
SLC22A6 Q4U2R8 1/20 0.35
TSHR P16473 4/20 0.34
KDM4E B2RXH2 3/20 0.33
FOLH1 Q04609 1/20 0.33
NFKB1 P19838 1/20 0.33
PMP22 Q01453 1/20 0.33
GABRR1 P24046 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5580355 0.89 ALDH1A1 (0.48) LMNAALDH1A1TSHRKDM4EPMP22
SCHEMBL288701 0.87 LMNA (0.60) EGLN1LMNAALKBH5SUCNR1KDM5C
SCHEMBL1992862 0.87 LMNA (0.60) EGLN1LMNAALKBH5SUCNR1KDM5C
SCHEMBL27749051 0.84 LMNA (0.56) EGLN1LMNAALKBH5SUCNR1KDM5C
SCHEMBL27705671 0.84 LMNA (0.56) EGLN1LMNAALKBH5SUCNR1KDM5C
Ammonia Solution, Strong SCHEMBL28163791 0.84 LMNA (0.56) EGLN1LMNAALKBH5SUCNR1KDM5C
SCHEMBL2218408 0.84 LMNA (0.56) EGLN1LMNAALKBH5SUCNR1KDM5C
SCHEMBL56558 0.81
SCHEMBL429060 0.79 LMNA (0.53) EGLN1LMNAALKBH5SUCNR1KDM5C
SCHEMBL2209527 0.79 TSHR (0.54) EGLN1LMNAALKBH5SUCNR1KDM5C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4199968-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF Ambrx, Inc. (US) 2023-06-28 EP disclosed
WO-2022040596-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF AMBRX, INC. (US) 2022-02-24 WO disclosed
EP-3923991-A1 COMPOSITIONS CONTAINING, METHODS AND USES OF ANTIBODY-TLR AGONIST CONJUGATES Ambrx, Inc. (US) 2021-12-22 EP disclosed
EP-3849592-A1 MODIFIED IFNL3 POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCING MOIETY AND THEIR USES Exalt Therapeutics, LLC (US) 2021-07-21 EP disclosed
WO-2020168017-A1 COMPOSITIONS CONTAINING, METHODS AND USES OF ANTIBODY-TLR AGONIST CONJUGATES AMBRX, INC. (US) 2020-08-20 WO disclosed
WO-2020041636-A1 MODIFIED IFNL3 POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCING MOIETY AND THEIR USES EXALT THERAPEUTICS, LLC (US) 2020-02-27 WO disclosed
EP-2861259-A1 ANTI-PSMA ANTIBODIES CONJUGATED TO NUCLEAR RECEPTOR LIGAND POLYPEPTIDES Ambrx, Inc. (US) 2015-04-22 EP disclosed
EP-2780031-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING GLUCOCORTICOID RECEPTOR ACTIVITY Indiana University Research and Technology Corporation (US) 2014-09-24 EP disclosed
WO-2013188740-A1 ANTI-PSMA ANTIBODIES CONJUGATED TO NUCLEAR RECEPTOR LIGAND POLYPEPTIDES AMBRX, INC. (US) 2013-12-19 WO disclosed
WO-2013074910-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING GLUCOCORTICOID RECEPTOR ACTIVITY INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2013-05-23 WO disclosed
EP-2568993-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING G PROTEIN-COUPLED RECEPTOR ACTIVITY Indiana University Research and Technology Corporation (US) 2013-03-20 EP disclosed
EP-2569000-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING NUCLEAR HORMONE RECEPTOR ACTIVITY Indiana University Research and Technology Corporation (US) 2013-03-20 EP disclosed
WO-2011143208-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING G PROTEIN-COUPLED RECEPTOR ACTIVITY INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2011-11-17 WO disclosed
WO-2011143209-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING NUCLEAR HORMONE RECEPTOR ACTIVITY INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2011-11-17 WO disclosed