Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | GAA | P10253 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421071 | 0.92 | ALDH1A1 (0.38) | SMN1; SMN2HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL1586060 | 0.88 | GAA (0.35) | MAPTGAAKDM4EMEN1KMT2A | |
| SCHEMBL10345296 | 0.86 | ALDH1A1 (0.37) | SMN1; SMN2HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL9924955 | 0.84 | HSP90AA1 (0.34) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL930153 | 0.83 | HSP90AA1 (0.34) | SMN1; SMN2MAPTGAAKDM4EMEN1 | |
| SCHEMBL15940226 | 0.82 | MAP3K11 (0.39) | SMN1; SMN2MAPTGAAKDM4EMEN1 | |
| SCHEMBL3701216 | 0.81 | MAPT (0.35) | HSD17B10MAPTGAAKDM4EMEN1 | |
| SCHEMBL931175 | 0.80 | HTR1A (0.34) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL12694836 | 0.80 | MAP3K11 (0.39) | MAPTGAAKDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL13983495 | 0.80 | HSP90AA1 (0.33) | MAPTGAAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146801-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-24 | — | — | WO | claimed |