Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421071 | 0.88 | ALDH1A1 (0.38) | HSP90AA1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL1586060 | 0.86 | GAA (0.35) | HSP90AA1HSP90AB1MEN1ALDH1A1POLB | |
| SCHEMBL2596695 | 0.84 | SMN1; SMN2 (0.37) | HSP90AA1HSP90AB1MEN1ALDH1A1POLB | |
| SCHEMBL10345296 | 0.82 | ALDH1A1 (0.37) | HSP90AA1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL930153 | 0.80 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1MEN1ALDH1A1POLB | |
| SCHEMBL931175 | 0.79 | HTR1A (0.34) | HSP90AA1HSP90AB1ALDH1A1GAAMAPT | |
| SCHEMBL15940226 | 0.79 | MAP3K11 (0.39) | HSP90AA1HSP90AB1MEN1ALDH1A1GAA | |
| SCHEMBL12694836 | 0.79 | MAP3K11 (0.39) | HSP90AA1HSP90AB1GAAMAPTNPSR1 | |
| SCHEMBL3701216 | 0.78 | MAPT (0.35) | HSP90AA1HSP90AB1MEN1ALDH1A1GAA | |
| SCHEMBL421098 | 0.77 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012116247-A1 | HSP90 INHIBITORY COMPOUNDS IN TREATING JAK/STAT SIGNALING-MEDIATED CANCERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-08-30 | — | — | WO | disclosed |
| WO-2012116061-A1 | COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH RADIOTHERAPY | SYNTA PHARMACEUTICALS CORP. (US) | 2012-08-30 | — | — | WO | disclosed |
| WO-2012078757-A2 | COMBINATION BREAST CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011146801-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2007139960-A2 | COMPOUNDS THAT MODULATE HSP90 ACTIVITY AND METHODS FOR IDENTIFYING SAME | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |