Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 10/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597138 | 0.84 | GPR119 (0.36) | GPR119SCN5ASCN9A | |
| SCHEMBL14918086 | 0.80 | SCN5A (0.36) | GPR119SCN5ASCN9A | |
| SCHEMBL2597298 | 0.79 | NR1H2 (0.41) | GPR119SCN9A | |
| SCHEMBL14918043 | 0.79 | NR1H2 (0.34) | GPR119SCN5ASCN9A | |
| SCHEMBL2597057 | 0.77 | GPR119 (0.41) | GPR119 | |
| SCHEMBL15022693 | 0.77 | GPR119 (0.41) | GPR119 | |
| SCHEMBL790469 | 0.73 | SCN9A (0.34) | SCN5ADPP4SCN9A | |
| SCHEMBL788886 | 0.73 | SCN9A (0.34) | SCN5ADPP4SCN9A | |
| SCHEMBL2597007 | 0.72 | GPR119 (0.35) | GPR119DPP4 | |
| SCHEMBL2597290 | 0.70 | GPR119 (0.41) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |