SCHEMBL2597290

SCHEMBL2597290

CCc1cnc(N2CCC(N3CCCC3=O)[C@H](N(C)c3cc(F)c(S(C)(=O)=O)cc3F)C2)nc1

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.41
NR1H2 P55055 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15022671 0.78 GPR119 (0.48) GPR119
SCHEMBL15023417 0.76 GPR119 (0.47) GPR119
SCHEMBL2597289 0.76 GPR119 (0.47) GPR119
SCHEMBL2597410 0.73 DPP4 (0.45) GPR119
SCHEMBL15022721 0.72 GPR119 (0.39) GPR119NR1H2
SCHEMBL15022722 0.72 GPR119 (0.39) GPR119NR1H2
SCHEMBL15044987 0.71 GPR119 (0.46) GPR119
Trifluoroacetic Acid SCHEMBL2597233 0.71 GPR119 (0.43) GPR119
SCHEMBL2597058 0.70 GPR119 (0.37) GPR119
SCHEMBL2597007 0.69 GPR119 (0.35) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2571864-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS Array Biopharma, Inc. (US) 2013-03-27 EP disclosed
WO-2011146335-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS ARRAY BIOPHARMA INC. (US) 2011-11-24 WO disclosed