Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 12/20 | 0.34 |
| ▸ | SCN2B | O60939 | 7/20 | 0.32 |
| ▸ | SCN1B | Q07699 | 7/20 | 0.32 |
| ▸ | SCN1A | P35498 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788886 | 1.00 | SCN9A (0.34) | SCN9ASCN2BSCN1BSCN1AKCNH2 | |
| SCHEMBL789192 | 0.85 | GPR119 (0.40) | HTR2C | |
| Hydrochloric Acid SCHEMBL2597110 | 0.84 | GPR119 (0.40) | HTR2C | |
| Hydrochloric Acid SCHEMBL789439 | 0.81 | SLC9A3 (0.32) | — | |
| SCHEMBL789053 | 0.80 | SCN9A (0.32) | SCN9A | |
| Hydrochloric Acid SCHEMBL2597053 | 0.80 | TSHR (0.31) | — | |
| Hydrochloric Acid SCHEMBL14917661 | 0.79 | BRD4 (0.35) | KCNH2HTR2CHTR2B | |
| SCHEMBL789678 | 0.77 | SCN9A (0.33) | SCN9ADPP4 | |
| SCHEMBL2597088 | 0.75 | F10 (0.31) | — | |
| SCHEMBL789143 | 0.74 | GPR119 (0.39) | KCNH2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616074-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2013066869-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-10 | — | — | WO | disclosed |
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2012037393-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |