Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | GRN | P28799 | 2/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MARS1 | P56192 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15056101 | 0.87 | P2RY14 (0.53) | MALT1GRNSORT1POLBKMT2A | |
| SCHEMBL17324801 | 0.84 | AURKA (0.52) | MALT1GRNSORT1POLBKMT2A | |
| SCHEMBL25972441 | 0.82 | CYP19A1 (0.44) | POLBKMT2A | |
| SCHEMBL13373558 | 0.81 | SMN1; SMN2 (0.58) | POLBKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL25972165 | 0.80 | P2RY14 (0.44) | P2RY14TP53 | |
| SCHEMBL25972032 | 0.80 | AURKA (0.42) | KMT2AMEN1P2RY14SMN1; SMN2MARS1 | |
| SCHEMBL2845945 | 0.78 | POLB (0.50) | GRNSORT1POLBKMT2AMEN1 | |
| SCHEMBL8192476 | 0.78 | KMT2A (0.58) | POLBKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL2208700 | 0.77 | GRN (0.46) | MALT1GRNSORT1POLBKMT2A | |
| SCHEMBL12402397 | 0.77 | PTGS2 (0.48) | GRNSORT1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718612-B2 | Inhibitors of receptor interacting protein kinase I for the treatment of disease | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718612-B2 | Inhibitors of receptor interacting protein kinase I for the treatment of disease | RIPK1, RIPK2, RIPK4 | MALT1 2349/4885GRN 1091/4885SORT1 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.