Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15378035 | 0.89 | MTNR1A (0.45) | MTNR1AMTNR1BCYP4F2CYP4A11HSP90AB1 | |
| SCHEMBL17802775 | 0.86 | MTNR1A (0.40) | MTNR1AMTNR1BCYP4F2CYP4A11HSP90AB1 | |
| SCHEMBL15383526 | 0.85 | MTNR1A (0.39) | MTNR1AMTNR1BCYP4F2CYP4A11HSP90AB1 | |
| SCHEMBL25941174 | 0.85 | MTNR1A (0.42) | MTNR1AMTNR1BCYP4F2CYP4A11CTSS | |
| SCHEMBL17999509 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BCYP4F2CYP4A11RIPK1 | |
| SCHEMBL27394889 | 0.81 | KDM4E (0.50) | MTNR1AMTNR1BMEN1KMT2ACTSS | |
| SCHEMBL27478049 | 0.79 | CYP4F2 (0.46) | CYP4F2CYP4A11HSP90AB1MEN1KMT2A | |
| SCHEMBL1115348 | 0.79 | HSP90AB1 (0.62) | CYP4F2CYP4A11HSP90AB1MEN1KMT2A | |
| SCHEMBL22774259 | 0.78 | MTNR1A (0.42) | MTNR1AMTNR1BHSP90AB1RIPK1RIPK3 | |
| SCHEMBL19974287 | 0.78 | MTNR1A (0.42) | MTNR1AMTNR1BHSP90AB1RIPK1RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718612-B2 | Inhibitors of receptor interacting protein kinase I for the treatment of disease | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718612-B2 | Inhibitors of receptor interacting protein kinase I for the treatment of disease | RIPK1, RIPK2, RIPK4 | MTNR1A 2091/4885MTNR1B 2672/4885CYP4F2 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.