Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597413 | 0.81 | GPR119 (0.41) | GPR119KCNH2CCNA2CDK2CDK5 | |
| SCHEMBL2597062 | 0.81 | SLC6A9 (0.38) | GPR119KCNH2SLC6A9NR1H2NR1H3 | |
| SCHEMBL2597223 | 0.77 | GPR119 (0.42) | GPR119KCNH2SLC6A9GPR6 | |
| SCHEMBL15022888 | 0.77 | GPR119 (0.42) | GPR119KCNH2SLC6A9GPR6 | |
| SCHEMBL789216 | 0.74 | SLC6A9 (0.34) | GPR119SLC6A9CCNA2CDK2CDK5 | |
| SCHEMBL2597109 | 0.71 | SLC6A9 (0.37) | GPR119SLC6A9CCNA2CDK2CDK5 | |
| SCHEMBL15023425 | 0.67 | GPR119 (0.42) | GPR119KCNH2 | |
| SCHEMBL15023345 | 0.67 | GPR119 (0.43) | GPR119KCNH2SLC6A9CCNA2CDK2 | |
| SCHEMBL12185783 | 0.67 | GPR119 (0.43) | GPR119KCNH2SLC6A9CCNA2CDK2 | |
| SCHEMBL15047699 | 0.67 | GPR119 (0.42) | GPR119KCNH2CCNA2CDK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |