Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597062 | 0.82 | SLC6A9 (0.38) | GPR119KCNH2CCNA2CDK2CDK5 | |
| SCHEMBL2597224 | 0.81 | DPP4 (0.37) | GPR119KCNH2CCNA2CDK2CDK5 | |
| SCHEMBL15022719 | 0.76 | GPR119 (0.45) | GPR119KCNH2CYP3A4 | |
| SCHEMBL2597412 | 0.76 | GPR119 (0.45) | GPR119KCNH2CYP3A4 | |
| SCHEMBL789216 | 0.75 | SLC6A9 (0.34) | GPR119CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL2597109 | 0.72 | SLC6A9 (0.37) | GPR119CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL15023424 | 0.68 | GPR119 (0.46) | GPR119KCNH2CYP3A4 | |
| SCHEMBL790391 | 0.67 | BRD4 (0.33) | GPR119CDK2 | |
| SCHEMBL15022657 | 0.67 | GPR119 (0.50) | GPR119KCNH2 | |
| SCHEMBL15023116 | 0.67 | GPR119 (0.54) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |