Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185889 | 0.81 | GPR119 (0.44) | GPR119 | |
| SCHEMBL2597007 | 0.74 | GPR119 (0.35) | DPP4GPR119 | |
| SCHEMBL12503204 | 0.73 | HRH4 (0.47) | DPP4PDE8BGPR119 | |
| SCHEMBL2597290 | 0.73 | GPR119 (0.41) | GPR119 | |
| SCHEMBL2598361 | 0.71 | GPR119 (0.40) | DPP4PDE8BGPR119 | |
| SCHEMBL2597089 | 0.70 | OGA (0.42) | PDE8BGPR119 | |
| SCHEMBL12525153 | 0.69 | GPR119 (0.40) | GPR119 | |
| SCHEMBL904092 | 0.68 | PDE8B (0.41) | PDE8BGPR119 | |
| SCHEMBL15312801 | 0.68 | AOC3 (0.49) | PDE8BGPR119 | |
| SCHEMBL12506042 | 0.68 | AOC3 (0.49) | PDE8BGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |