SCHEMBL25975294 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	NT5E	P21589	1/20	0.44

▸	HTT	P42858	1/20	0.41

▸	PTGS2	P35354	10/20	0.39

▸	HSD11B1	P28845	5/20	0.38

▸	RXRA	P19793	1/20	0.36

▸	NR1H2	P55055	1/20	0.36

▸	NR1H3	Q13133	1/20	0.36

▸	PDE2A	O00408	2/20	0.36

▸	PTGS1	P23219	4/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL27031631	0.86	HTT (0.43)	NT5EHTTPTGS2PTGS1
SCHEMBL25198784	0.84	HTT (0.42)	NT5EHTTPTGS2HSD11B1PTGS1
SCHEMBL25975187	0.81	MC4R (0.45)	HTTPTGS2PTGS1
SCHEMBL25344707	0.81	USP1 (0.40)	PTGS2HSD11B1
SCHEMBL25346673	0.80	PTGS2 (0.40)	PTGS2HSD11B1RXRANR1H2NR1H3
SCHEMBL25343216	0.80	USP1 (0.39)	PTGS2HSD11B1
SCHEMBL10177256	0.80	NT5E (0.42)	NT5EPTGS2HSD11B1RXRANR1H2
SCHEMBL30615104	0.80	USP1 (0.39)	PTGS2HSD11B1
SCHEMBL30615090	0.80	PTGS2 (0.40)	PTGS2HSD11B1RXRANR1H2NR1H3
SCHEMBL25975478	0.80	EGLN2 (0.38)	PTGS2HSD11B1RXRANR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023148643-A1	FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS USP1 INHIBITORS	AURIGENE ONCOLOGY LIMITED (IN)	2023-08-10	—	—	WO	disclosed