Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25975832 | 0.82 | PDCD1 (0.42) | LMNAMAPTTP53ADORA2AADORA1 | |
| SCHEMBL14566140 | 0.80 | ADORA2A (0.40) | LMNAMAPTTP53ADORA2AADORA1 | |
| SCHEMBL14566143 | 0.80 | CDK4 (0.41) | LMNAMAPTTP53ADORA2AADORA1 | |
| SCHEMBL25975828 | 0.78 | CDK4 (0.38) | LMNAMAPTTP53ADORA2AADORA1 | |
| SCHEMBL26032299 | 0.78 | POLB (0.41) | LMNAMAPTTP53ADORA2AADORA1 | |
| SCHEMBL18098800 | 0.78 | ADORA2A (0.39) | LMNAMAPTTP53ADORA2AADORA1 | |
| SCHEMBL14853093 | 0.77 | CYP2C19 (0.45) | LMNAMAPTADORA2AADORA1POLB | |
| SCHEMBL14853336 | 0.75 | HRH3 (0.37) | LMNAADORA2AADORA1POLBDRD2 | |
| SCHEMBL14853095 | 0.73 | MEN1 (0.60) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL22739185 | 0.72 | ADORA2A (0.33) | LMNAADORA2AADORA1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |