Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 7/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21622307 | 0.88 | JAK2 (0.34) | PDCD1CD274ADORA2AADORA1LMNA | |
| SCHEMBL25975830 | 0.82 | LMNA (0.40) | ADORA2AADORA1LMNAPOLBMAPT | |
| SCHEMBL14566140 | 0.82 | ADORA2A (0.40) | ADORA2AADORA1LMNAPOLBMAPT | |
| SCHEMBL14566143 | 0.82 | CDK4 (0.41) | ADORA2AADORA1LMNAPOLBMAPT | |
| SCHEMBL18098800 | 0.80 | ADORA2A (0.39) | ADORA2AADORA1LMNAPOLBMAPT | |
| SCHEMBL31362283 | 0.79 | PDCD1 (0.38) | PDCD1CD274LMNAMAPTCYP2C19 | |
| SCHEMBL14853093 | 0.79 | CYP2C19 (0.45) | ADORA2AADORA1LMNAPOLBMAPT | |
| SCHEMBL25975828 | 0.78 | CDK4 (0.38) | ADORA2AADORA1LMNAPOLBMAPT | |
| SCHEMBL26032299 | 0.78 | POLB (0.41) | ADORA2AADORA1LMNAPOLBMAPT | |
| SCHEMBL14853336 | 0.78 | HRH3 (0.37) | ADORA2AADORA1LMNAPOLBCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |