Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22993429 | 0.90 | POLB (0.35) | POLBMAPTPRMT5WDR77GPR6 | |
| SCHEMBL26640563 | 0.82 | POLB (0.38) | POLBMAPTLMNAPRMT5TP53 | |
| SCHEMBL25975828 | 0.79 | CDK4 (0.38) | POLBMAPTADORA2AADORA1LMNA | |
| SCHEMBL25975830 | 0.78 | LMNA (0.40) | POLBMAPTADORA2AADORA1LMNA | |
| SCHEMBL25975832 | 0.78 | PDCD1 (0.42) | POLBMAPTADORA2AADORA1LMNA | |
| SCHEMBL26640442 | 0.77 | POLB (0.38) | POLBMAPTLMNAPRMT5 | |
| SCHEMBL14853336 | 0.77 | HRH3 (0.37) | POLBADORA2AADORA1LMNACDK1 | |
| SCHEMBL26032152 | 0.76 | PRMT5 (0.46) | POLBPRMT5WDR77ASIC3 | |
| SCHEMBL14566143 | 0.75 | CDK4 (0.41) | POLBMAPTADORA2AADORA1LMNA | |
| SCHEMBL14566140 | 0.75 | ADORA2A (0.40) | POLBMAPTADORA2AADORA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |