Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 6/20 | 0.49 |
| ▸ | NCF1 | P14598 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973439 | 0.85 | KEAP1 (0.67) | KEAP1NFE2L2MAOBST14 | |
| SCHEMBL4061378 | 0.85 | NQO1 (0.57) | NCF1THRAACACBMEN1USP2 | |
| SCHEMBL9782223 | 0.85 | TAAR1 (0.53) | MAOBNCF1MEN1USP2ALDH1A1 | |
| SCHEMBL9150174 | 0.83 | KDM4E (0.56) | NCF1APPTHRAMEN1USP2 | |
| SCHEMBL26659483 | 0.83 | KEAP1 (0.56) | KEAP1NFE2L2MAOBAPP | |
| SCHEMBL19928241 | 0.82 | ALDH1A1 (0.51) | NCF1APPTHRAACACBMEN1 | |
| SCHEMBL21100939 | 0.82 | KEAP1 (0.55) | KEAP1NFE2L2MAOBAPPST14 | |
| SCHEMBL10562624 | 0.82 | SLC6A4 (0.56) | MAOBACACB | |
| SCHEMBL1157194 | 0.82 | KEAP1 (0.63) | KEAP1NFE2L2MAOBSMN1; SMN2 | |
| SCHEMBL2911524 | 0.82 | KEAP1 (0.63) | KEAP1NFE2L2MAOBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023148643-A1 | FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS USP1 INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-08-10 | — | — | WO | disclosed |