Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SCN1A | P35498 | 1/20 | 0.55 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20401753 | 0.84 | SMN1; SMN2 (0.57) | MAPTNAPRTHSD17B10GAAL3MBTL1 | |
| SCHEMBL9121361 | 0.83 | MAPT (0.85) | MAPTNAPRTHSD17B10EPHX2KDM1A | |
| SCHEMBL14914 | 0.83 | MAPT (0.85) | MAPTNAPRTHSD17B10EPHX2KDM1A | |
| SCHEMBL3021545 | 0.83 | MAPT (0.67) | MAPTNAPRTHSD17B10EPHX2KDM1A | |
| SCHEMBL1689206 | 0.83 | EPHX2 (0.68) | MAPTEPHX2KDM1AGAASCN1A | |
| SCHEMBL19659854 | 0.82 | POLB (0.74) | GAAHTTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL587369 | 0.82 | MAPT (0.82) | MAPTNAPRTHSD17B10EPHX2KDM1A | |
| SCHEMBL28996270 | 0.82 | MAPT (0.82) | MAPTNAPRTHSD17B10EPHX2KDM1A | |
| SCHEMBL3074308 | 0.82 | EPHX2 (0.57) | MAPTEPHX2KDM1AGAASCN1A | |
| Hydrochloric Acid SCHEMBL28406796 | 0.82 | MAPT (0.82) | MAPTNAPRTHSD17B10EPHX2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024103151-A1 | 1H-PYRAZOLE ANALOGUES AND METHODS AND USES THEREOF | UNIVERSITY OF MANITOBA (CA) | 2024-05-23 | — | — | WO | disclosed |
| US-20230255970-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | THE BROAD INSTITUTE, INC. (US) | 2023-08-17 | — | — | US | disclosed |
| US-20230255970-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | THE BROAD INSTITUTE, INC. (US) | 2023-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230255970-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | YAP1, RELA, NFKBIA | MAPT 1438/4885NAPRT 2648/4885HSD17B10 1385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.