Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 5/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.45 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598615 | 0.93 | JAK2 (0.45) | JAK2TBK1RIPK2CTSLCTSB | |
| SCHEMBL2597569 | 0.87 | CCNT1 (0.52) | JAK2TBK1RIPK2CTSLCTSB | |
| SCHEMBL2597585 | 0.87 | HDAC3 (0.48) | JAK2TBK1CTSLCTSBCTSS | |
| SCHEMBL31054180 | 0.87 | CCNT1 (0.52) | JAK2TBK1RIPK2CTSLCTSB | |
| SCHEMBL2597598 | 0.83 | HDAC3 (0.53) | JAK2TBK1RIPK2CTSLCTSB | |
| SCHEMBL2597549 | 0.79 | CCNT1 (0.43) | JAK2TBK1RIPK2CTSLCTSB | |
| SCHEMBL2597608 | 0.78 | CCNT1 (0.47) | JAK2TBK1HDAC3HDAC1HDAC2 | |
| SCHEMBL2597604 | 0.78 | CCNT1 (0.47) | JAK2TBK1RIPK2CTSLCTSB | |
| SCHEMBL2597767 | 0.77 | CCNT1 (0.42) | JAK2TBK1RIPK2HDAC3HDAC1 | |
| SCHEMBL2597649 | 0.74 | CCNT1 (0.45) | JAK2RIPK2HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571856-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | claimed |
| WO-2011144577-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | claimed |
| EP-2571856-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144577-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011144577-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |