Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597583 | 0.90 | CCNT1 (0.44) | CCNT1CDK2CDK9CCNE1NTRK1 | |
| SCHEMBL2597585 | 0.89 | HDAC3 (0.48) | CCNT1CDK2CDK9CCNE1NTRK1 | |
| SCHEMBL31054180 | 0.86 | CCNT1 (0.52) | CCNT1CDK2CDK9CCNE1NTRK1 | |
| SCHEMBL2597569 | 0.86 | CCNT1 (0.52) | CCNT1CDK2CDK9CCNE1NTRK1 | |
| SCHEMBL2597549 | 0.81 | CCNT1 (0.43) | CCNT1CDK2CDK9CCNE1NTRK1 | |
| SCHEMBL2598615 | 0.78 | JAK2 (0.45) | CCNT1CDK2CDK9CCNE1HDAC3 | |
| SCHEMBL2597608 | 0.78 | CCNT1 (0.47) | CCNT1CDK2CDK9CCNE1HDAC3 | |
| SCHEMBL2597630 | 0.77 | JAK2 (0.51) | CCNT1CDK2CDK9CCNE1HDAC3 | |
| SCHEMBL2597649 | 0.77 | CCNT1 (0.45) | CCNT1CDK2CDK9CCNE1NTRK1 | |
| SCHEMBL2597598 | 0.75 | HDAC3 (0.53) | CCNT1CDK2CDK9CCNE1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571856-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144577-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |