Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16017176 | 0.86 | STIM1 (0.41) | POLBMAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL14881540 | 0.85 | HTT (0.56) | POLBMAPTSMN1; SMN2PTGS2ROCK1 | |
| SCHEMBL21332304 | 0.79 | PTGS2 (0.53) | POLBMAPTSMN1; SMN2PTGS2ROCK1 | |
| SCHEMBL16017415 | 0.77 | MAPT (0.55) | POLBMAPTSMN1; SMN2ROCK1THRB | |
| SCHEMBL14881420 | 0.77 | STIM1 (0.53) | POLBMAPTSMN1; SMN2PTGS2ROCK1 | |
| SCHEMBL16017416 | 0.76 | STIM1 (0.66) | POLBMAPTSMN1; SMN2PTGS2ROCK1 | |
| SCHEMBL14887702 | 0.76 | STIM1 (0.50) | POLBMAPTSMN1; SMN2PTGS2ROCK1 | |
| SCHEMBL14887780 | 0.76 | MAPT (0.57) | POLBMAPTSMN1; SMN2ROCK1THRB | |
| SCHEMBL16017417 | 0.75 | MAPT (0.52) | POLBMAPTSMN1; SMN2PTGS2ROCK1 | |
| SCHEMBL25384454 | 0.75 | HTT (0.51) | POLBMAPTSMN1; SMN2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11752148-B2 | Pyrazine-containing compound | CALCIMEDICA, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20230226058-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE KIDNEY INJURY | AVENUE CAPITAL MANAGEMENT II, L.P. | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11752148-B2 | Pyrazine-containing compound | NFATC1, IAPP, NLRP3 | POLB 4827/4885MAPT 3453/4885SMN1; SMN2 3099/4885 |
| US-20230226058-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE KIDNEY INJURY | CAMKK2, CAMKK1, ATF1 | POLB 4815/4885MAPT 4289/4885SMN1; SMN2 4791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.