Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392263 | 0.86 | DRD4 (0.70) | DRD4SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6031812 | 0.84 | DRD4 (1.00) | DRD4SIGMAR1DRD2DRD3HTR7 | |
| SCHEMBL5542706 | 0.83 | DRD4 (0.77) | DRD4SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL3320211 | 0.82 | DRD4 (0.74) | DRD4SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL588149 | 0.81 | DRD4 (1.00) | DRD4SIGMAR1HTR2CL3MBTL1DRD2 | |
| SCHEMBL6794331 | 0.81 | DRD4 (0.79) | DRD4SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL4539667 | 0.81 | ITGB3 (0.71) | DRD4SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL654308 | 0.80 | DRD4 (0.77) | DRD4SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL5548733 | 0.80 | DRD4 (0.77) | DRD4SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL3242187 | 0.80 | DRD4 (0.77) | DRD4SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162461-A1 | PHENYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-29 | — | — | WO | disclosed |
| WO-2011146401-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-11-24 | — | — | WO | disclosed |