Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.54 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1540225 | 0.88 | DRD4 (0.54) | DRD4ALDH1A1MAPTKDM4EDRD2 | |
| SCHEMBL2597773 | 0.86 | DRD4 (0.72) | DRD4HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL23922755 | 0.85 | POLB (0.63) | DRD4TRIM24TRIM33ALDH1A1MAPT | |
| SCHEMBL28710553 | 0.83 | HDAC3 (0.57) | DRD4ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL1443539 | 0.83 | TRIM24 (0.70) | TRIM24TRIM33ALDH1A1MEN1MAPT | |
| SCHEMBL6031812 | 0.83 | DRD4 (1.00) | DRD4SIGMAR1ALDH1A1HTR7KDM4E | |
| SCHEMBL5542706 | 0.82 | DRD4 (0.77) | DRD4HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL27990811 | 0.81 | HRH3 (0.52) | DRD4SIGMAR1TRIM24TRIM33ALDH1A1 | |
| SCHEMBL1540315 | 0.80 | HTR7 (0.74) | DRD4TRIM24TRIM33ALDH1A1HTR7 | |
| SCHEMBL588149 | 0.80 | DRD4 (1.00) | DRD4HTR2CSIGMAR1ALDH1A1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11660303-B2 | 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity | KANCERA AB (SE) | 2023-05-30 | — | — | US | disclosed |
| EP-3481824-B1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2021-10-20 | — | — | EP | disclosed |
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| US-11008318-B2 | 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity | KANCERA AB (SE) | 2021-05-18 | — | — | US | disclosed |
| EP-3481824-A1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | Kancera AB (SE) | 2019-05-15 | — | — | EP | disclosed |
| WO-2018011138-A1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2018-01-18 | — | — | WO | disclosed |
| US-20090011977-A1 | Novel Lipopeptides as Antibacterial Agents | HILL JASON | 2009-01-08 | — | — | US | disclosed |
| US-20080287347-A1 | Novel Lipopeptides as Antibacterial Agents | CUBIST PHARMACEUTICALS, INC. | 2008-11-20 | — | — | US | disclosed |
| US-7432263-B2 | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | PFIZER ITALIA, S.R.L. (IT) | 2008-10-07 | — | — | US | disclosed |
| EP-1427708-B1 | AMINO-PHTHALAZINONE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER ITALIA SRL (IT) | 2008-09-10 | — | — | EP | disclosed |
| US-7408025-B2 | Lipopeptides as antibacterial agents | CUBIST PHARMACEUTICALS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
| US-20050020583-A1 | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | PFIZER ITALIA S.R.L. (IT) | 2005-01-27 | — | — | US | disclosed |
| US-20040067878-A1 | Novel lipopeptides as antibacterial agents | MERCK SHARP & DOHME CORP. | 2004-04-08 | — | — | US | disclosed |
| EP-1246838-A1 | LIPOPEPTIDES AS ANTIBACTERIAL AGENTS | Cubist Pharmaceuticals, Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-0869942-B1 | 4-((HETEROCYCLOALKYL OR HETEROAROMATIC)-SUBSTITUTED PHENYL]-2-AZETIDINONES USEFUL AS HYPOLIPIDEMIC AGENTS | SCHERING CORP (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2001044274-A1 | LIPOPEPTIDES AS ANTIBACTERIAL AGENTS | CUBIST PHARMACEUTICALS, INC. (US) | 2001-06-21 | — | — | WO | disclosed |
| EP-0869942-A1 | 4-((HETEROCYCLOALKYL OR HETEROAROMATIC)-SUBSTITUTED PHENYL]-2-AZETIDINONES USEFUL AS HYPOLIPIDEMIC AGENTS | SCHERING CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| US-5656624-A | ADMINISTERING TO LOWER SERUM CHOLESTEROL LEVELS | SCHERING CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| WO-1996019450-A1 | 4-[(HETEROCYCLOALKYL OR HETEROAROMATIC)-SUBSTITUTED PHENYL]-2-AZETIDINONES USEFUL AS HYPOLIPIDEMIC AGENTS | SCHERING CORPORATION (US) | 1996-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | DRD4 4852/4885HTR2A 4710/4885HTR2C 4587/4885 |
| US-20080287347-A1 | Novel Lipopeptides as Antibacterial Agents | CLPTM1, NGLY1, VIP | DRD4 3790/4885HTR2A 4199/4885HTR2C 4680/4885 |
| US-20040067878-A1 | Novel lipopeptides as antibacterial agents | CLPTM1, NGLY1, VIP | DRD4 3790/4885HTR2A 4199/4885HTR2C 4680/4885 |
| US-20090011977-A1 | Novel Lipopeptides as Antibacterial Agents | CLPTM1, NGLY1, VIP | DRD4 3790/4885HTR2A 4199/4885HTR2C 4680/4885 |
| US-11008318-B2 | 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity | ROR1, RORB, RORA | DRD4 4661/4885HTR2A 4409/4885HTR2C 3287/4885 |
| US-20050020583-A1 | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | MAP3K20, MAP3K1, MAP3K15 | DRD4 4653/4885HTR2A 4278/4885HTR2C 4409/4885 |
| US-11660303-B2 | 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity | ROR1, RORB, RORA | DRD4 4664/4885HTR2A 4398/4885HTR2C 3296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.