Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14976218 | 0.78 | CCNB2 (0.49) | NPC1ALDH1A1RAB9ANPY5R | |
| SCHEMBL20516529 | 0.77 | RIPK2 (0.47) | RIPK2NPC1ALDH1A1PKMRAB9A | |
| SCHEMBL29871188 | 0.74 | CYP19A1 (0.45) | NPC1ALDH1A1PKMRAB9AL3MBTL1 | |
| SCHEMBL3765594 | 0.74 | CYP19A1 (0.45) | NPC1ALDH1A1PKMRAB9AL3MBTL1 | |
| SCHEMBL29871364 | 0.71 | F3 (0.48) | CDC7FFAR1 | |
| SCHEMBL3837963 | 0.71 | F3 (0.48) | CDC7FFAR1 | |
| SCHEMBL2598068 | 0.71 | MAPK14 (0.42) | PIM1NPC1ALDH1A1PKMRAB9A | |
| SCHEMBL12186618 | 0.71 | MAPK14 (0.42) | PIM1NPC1ALDH1A1PKMRAB9A | |
| SCHEMBL12186595 | 0.71 | MAPK14 (0.42) | PIM1NPC1ALDH1A1PKMRAB9A | |
| SCHEMBL3063545 | 0.70 | METAP2 (0.58) | NPC1ALDH1A1PKMRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815858-B2 | Heterocyclic flaviviridae virus inhibitors | GILEAD SCIENCES, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815858-B2 | Heterocyclic flaviviridae virus inhibitors | GILEAD SCIENCES, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815858-B2 | Heterocyclic flaviviridae virus inhibitors | GILEAD SCIENCES, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| EP-2571882-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | Gilead Sciences, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146817-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011146817-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | EIF2AK2, MAVS, ZC3HAV1 | RIPK2 2369/4885PIM1 1938/4885NPC1 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.