Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GPR39 | O43194 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804308 | 1.00 | F10 (0.53) | F10PRSS1DRD2DRD3SIGMAR1 | |
| SCHEMBL1804309 | 1.00 | F10 (0.53) | F10PRSS1DRD2DRD3SIGMAR1 | |
| SCHEMBL852326 | 0.91 | DRD2 (0.54) | F10DRD2DRD3SIGMAR1CHRM4 | |
| SCHEMBL12617166 | 0.90 | S1PR5 (0.53) | F10PRSS1FAAH | |
| SCHEMBL14351264 | 0.89 | F10 (0.49) | F10PRSS1FAAH | |
| SCHEMBL23951589 | 0.89 | RORC (0.56) | SIGMAR1CHRM4FAAHMAPT | |
| SCHEMBL28932944 | 0.89 | RORC (0.56) | SIGMAR1CHRM4FAAHMAPT | |
| SCHEMBL5110560 | 0.88 | RORC (0.57) | F10PRSS1CHRM4 | |
| SCHEMBL4661703 | 0.88 | RORC (0.57) | F10PRSS1CHRM4 | |
| SCHEMBL4661705 | 0.88 | RORC (0.57) | F10PRSS1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |