Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | GPR39 | O43194 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804308 | 0.91 | F10 (0.53) | DRD2DRD3SIGMAR1LMNAMAPT | |
| SCHEMBL2598185 | 0.91 | F10 (0.53) | DRD2DRD3SIGMAR1LMNAMAPT | |
| SCHEMBL1804309 | 0.91 | F10 (0.53) | DRD2DRD3SIGMAR1LMNAMAPT | |
| SCHEMBL2599329 | 0.90 | DRD2 (0.51) | DRD2DRD3SIGMAR1LMNAMAPT | |
| SCHEMBL23923817 | 0.88 | RORC (0.58) | DRD2DRD3SIGMAR1HTTFAAH | |
| SCHEMBL13362731 | 0.88 | RORC (0.58) | DRD2DRD3SIGMAR1HTTFAAH | |
| SCHEMBL1898230 | 0.85 | F10 (0.49) | F10CHRM4RORCS1PR5 | |
| SCHEMBL8313881 | 0.85 | DRD2 (0.55) | DRD2DRD3SIGMAR1MAPTS1PR5 | |
| SCHEMBL8313885 | 0.85 | DRD2 (0.55) | DRD2DRD3SIGMAR1MAPTS1PR5 | |
| SCHEMBL1895760 | 0.84 | CCR5 (0.57) | MAPTHTTF10FAAHRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |