Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 14/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 14/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 14/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 14/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 13/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 13/20 | 0.33 |
| ▸ | CHRNG | P07510 | 12/20 | 0.33 |
| ▸ | CHRND | Q07001 | 12/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15007138 | 1.00 | CHRNB2 (0.33) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL10473935 | 0.74 | — | — | |
| SCHEMBL9735953 | 0.70 | CHRNB2 (0.41) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL22647696 | 0.68 | CRBN (0.34) | CRBN | |
| SCHEMBL8612563 | 0.67 | PRKCA (0.42) | — | |
| SCHEMBL21726204 | 0.65 | — | — | |
| SCHEMBL762744 | 0.65 | — | — | |
| SCHEMBL21726203 | 0.65 | — | — | |
| SCHEMBL9965147 | 0.65 | — | — | |
| SCHEMBL3408372 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571859-A2 | HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE | Research Triangle Institute (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146821-A2 | 1 - PHENYLMORPHOLINE DERIVATIVES AS HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE | RESEARCH TRIANGLE INSTITUTE (US) | 2011-11-24 | — | — | WO | disclosed |
| US-5089614-A | Polysubstituted 2-morpholones | THE B. F. GOODRICH COMPANY (US) | 1992-02-18 | — | — | US | disclosed |
| US-4914232-A | FOR POLYMERS | THE B. F. GOODRICH COMPANY (US) | 1990-04-03 | — | — | US | disclosed |
| US-4528370-A | Polysubstituted 2-morpholones | NOVEON IP HOLDINGS CORP., FORMERLY KNOWN AS PMD HOLDINGS CORP. | 1985-07-09 | — | — | US | disclosed |