Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | HTR2C | P28335 | 5/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598339 | 1.00 | TGFBR1 (0.42) | TGFBR1HTR2AHTR2CHTR2BGRIN2B | |
| SCHEMBL2598395 | 0.80 | TGFBR1 (0.37) | TGFBR1GRIN2BLMNA | |
| SCHEMBL2598413 | 0.77 | LRRK2 (0.39) | GRIN2BSMN1; SMN2 | |
| SCHEMBL2598340 | 0.74 | TGFBR1 (0.46) | TGFBR1GRIN2B | |
| SCHEMBL2596838 | 0.70 | TGFBR1 (0.44) | TGFBR1 | |
| SCHEMBL22119118 | 0.67 | EGLN1 (0.36) | TGFBR1HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL22119121 | 0.67 | EGLN1 (0.36) | TGFBR1HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL22119590 | 0.67 | HTR2A (0.40) | TGFBR1HTR2AHTR2CHTR2B | |
| SCHEMBL22118993 | 0.67 | HTR2A (0.40) | TGFBR1HTR2AHTR2CHTR2B | |
| SCHEMBL25320454 | 0.62 | CSNK2A1 (0.38) | HTR2AHTR2CHTR2BLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |