Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596743 | 0.81 | TGFBR1 (0.39) | TGFBR1 | |
| SCHEMBL204268 | 0.79 | TGFBR1 (0.40) | TGFBR1CSNK2A1AURKAJAK1AURKB | |
| SCHEMBL2596741 | 0.78 | FFAR1 (0.38) | TGFBR1AURKAJAK1AURKB | |
| SCHEMBL203826 | 0.73 | TGFBR1 (0.40) | TGFBR1CSNK2A1 | |
| SCHEMBL2596981 | 0.72 | TGFBR1 (0.36) | TGFBR1 | |
| SCHEMBL2596820 | 0.72 | L3MBTL1 (0.30) | — | |
| SCHEMBL2598341 | 0.70 | TGFBR1 (0.42) | TGFBR1 | |
| SCHEMBL2598339 | 0.70 | TGFBR1 (0.42) | TGFBR1 | |
| SCHEMBL22118795 | 0.66 | CSNK2A1 (0.33) | TGFBR1CSNK2A1 | |
| SCHEMBL22245124 | 0.66 | CSNK2A1 (0.33) | TGFBR1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |