Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598395 | 0.80 | TGFBR1 (0.37) | GRIN2BGRIN1 | |
| SCHEMBL2598341 | 0.77 | TGFBR1 (0.42) | GRIN2BSMN1; SMN2 | |
| SCHEMBL2598340 | 0.74 | TGFBR1 (0.46) | GRIN2BNPC1MITF | |
| SCHEMBL2598455 | 0.72 | TUBB4A (0.35) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2596741 | 0.70 | FFAR1 (0.38) | LRRK2FFAR1TLR7 | |
| SCHEMBL31586679 | 0.68 | HDAC8 (0.38) | LRRK2NPC1MITFALDH1A1HTT | |
| SCHEMBL26220438 | 0.68 | EGLN1 (0.37) | LRRK2NPC1MITFALDH1A1HTT | |
| SCHEMBL26220440 | 0.68 | TUBB4A (0.36) | LRRK2TLR7 | |
| SCHEMBL23275517 | 0.67 | LRRK2 (0.41) | LRRK2FFAR1NPC1MITFALDH1A1 | |
| SCHEMBL27227839 | 0.66 | CYP11B1 (0.38) | LRRK2FFAR1TLR7PLK4PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |