Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861829 | 0.89 | HDAC2 (0.40) | PARP1 | |
| SCHEMBL1806636 | 0.85 | USP30 (0.42) | RORC | |
| SCHEMBL1806634 | 0.85 | USP30 (0.42) | RORC | |
| SCHEMBL860711 | 0.82 | CDK5 (0.36) | PARP1PARP3 | |
| SCHEMBL1805360 | 0.82 | RXRA (0.41) | JAK2 | |
| SCHEMBL1805365 | 0.82 | RXRA (0.41) | JAK2 | |
| SCHEMBL2599006 | 0.82 | PAX8 (0.41) | — | |
| SCHEMBL1805364 | 0.82 | RXRA (0.41) | JAK2 | |
| SCHEMBL1804297 | 0.82 | BRD4 (0.42) | — | |
| SCHEMBL1804301 | 0.82 | BRD4 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |