Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14719753 | 0.96 | LIPG (0.34) | LIPGCYP1A2METAP2CA12CA9 | |
| SCHEMBL2597134 | 0.89 | HAVCR2 (0.33) | HAVCR2 | |
| SCHEMBL1661230 | 0.84 | CYP1A2 (0.39) | LIPGCYP1A2METAP2CA12CA9 | |
| SCHEMBL2597069 | 0.79 | CYP1A2 (0.34) | LIPGCYP1A2METAP2CA12CA9 | |
| SCHEMBL1001057 | 0.78 | CYP1A2 (0.36) | CYP1A2METAP2CA12CA9HAVCR2 | |
| SCHEMBL2597063 | 0.77 | KDM4E (0.33) | LIPGCYP1A2METAP2CA12CA9 | |
| SCHEMBL2597332 | 0.76 | KDM4E (0.34) | LIPGCYP1A2METAP2CA12CA9 | |
| SCHEMBL2597235 | 0.76 | CCNK (0.35) | CA12CA9DDR1 | |
| SCHEMBL1661031 | 0.76 | CA12 (0.39) | CA12CA9DDR1 | |
| SCHEMBL2599352 | 0.75 | DDR1 (0.34) | CA12CA9DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571865-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | Novartis AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144666-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-11-24 | — | — | WO | disclosed |