Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDCBP | O00560 | 8/20 | 0.38 |
| ▸ | SDC2 | P34741 | 8/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25993979 | 0.91 | PRMT5 (0.33) | SDCBPSDC2POLBPRMT5WDR77 | |
| SCHEMBL25982147 | 0.90 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL26020707 | 0.83 | THRB (0.43) | SDCBPSDC2POLBMAPTTHRB | |
| SCHEMBL26024862 | 0.83 | SDCBP (0.42) | SDCBPSDC2POLBMAPTTHRB | |
| SCHEMBL25993239 | 0.82 | PRMT5 (0.35) | SDCBPSDC2MAPK1MAPTPRMT5 | |
| SCHEMBL25942761 | 0.82 | THRB (0.40) | SDCBPSDC2POLBMAPTTHRB | |
| SCHEMBL25996642 | 0.81 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL25989028 | 0.79 | — | — | |
| SCHEMBL24421564 | 0.79 | SDCBP (0.42) | SDCBPSDC2MAPTTHRBMEN1 | |
| SCHEMBL24421581 | 0.78 | THRB (0.41) | SDCBPSDC2POLBMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306111-A2 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2024-01-17 | — | — | EP | disclosed |
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |