Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 4/20 | 0.31 |
| ▸ | SDCBP | O00560 | 1/20 | 0.30 |
| ▸ | SDC2 | P34741 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25982147 | 0.99 | PRMT5 (0.34) | PRMT5WDR77MMP1MMP2MMP3 | |
| SCHEMBL25993526 | 0.91 | SDCBP (0.38) | PRMT5WDR77SDCBPSDC2POLB | |
| SCHEMBL25996642 | 0.91 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL25989028 | 0.89 | — | — | |
| SCHEMBL25986037 | 0.87 | THRB (0.33) | MMP1MMP2MMP3MMP7SDCBP | |
| SCHEMBL25993051 | 0.84 | PRMT5 (0.33) | PRMT5WDR77 | |
| SCHEMBL25993223 | 0.83 | THRB (0.33) | NAMPTSDCBPSDC2POLB | |
| SCHEMBL26017679 | 0.80 | THRB (0.41) | NAMPTSDCBPSDC2POLB | |
| SCHEMBL27123296 | 0.79 | — | — | |
| SCHEMBL24790325 | 0.78 | DRD2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306111-A2 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2024-01-17 | — | — | EP | disclosed |
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |