Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 12/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 12/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 10/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27569559 | 0.88 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNB4CHRNA3ALOX15 | |
| SCHEMBL24084075 | 0.86 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRNB4CHRNA3ALOX15 | |
| SCHEMBL22446850 | 0.78 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2387296 | 0.78 | KMT2A (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3ALOX15 | |
| SCHEMBL247201 | 0.78 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3DPP4 | |
| SCHEMBL3401455 | 0.77 | KMT2A (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3ALOX15 | |
| SCHEMBL23771190 | 0.76 | CHRNB2 (0.76) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2332604 | 0.75 | — | — | |
| SCHEMBL20130638 | 0.74 | ALOX15 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3ALOX15 | |
| SCHEMBL105245 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023152709-A1 | RNA POLYMERASE INHIBITORS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2023-08-17 | — | — | WO | disclosed |