Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26004653 | 0.79 | MAPK1 (0.43) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL26006884 | 0.78 | ERCC1 (0.67) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL24258086 | 0.76 | S1PR1 (0.70) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL26004927 | 0.76 | RAB9A (0.63) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL26004914 | 0.73 | TDP1 (0.62) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL26007127 | 0.71 | ERCC1 (0.41) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL24258005 | 0.71 | CYP1A2 (0.51) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL24258021 | 0.68 | ERCC1 (0.48) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL26004649 | 0.67 | MAPK1 (0.52) | MAPK1SMN1; SMN2RAB9AKMT2ATDP1 | |
| SCHEMBL17115018 | 0.65 | TSHR (0.55) | MAPK1RAB9ATDP1NPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265082-A1 | SUBSTITUTED 1,2,4-OXADIAZOLES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265082-A1 | SUBSTITUTED 1,2,4-OXADIAZOLES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | USP28, USP1, USP18 | MAPK1 829/4885SMN1; SMN2 796/4885RAB9A 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.